Bacco, tabacco, e Venere, portan l’uomo al cenere.
Literally: Baccus, tobacco, and Venus lead man to ash.
Baccus (or Dionysus in Greek) is the Greek god of wine, merrymaking and intoxication, or basically of having a good time. Venus (Aphrodite in Greek) is of course the goddess of love and beauty. Tobacco needs no translation. 🙂 So this proverb is saying that too much wine, tobacco, and women will lead a man to ruin.
I really should find less sexist proverbs. 🙂